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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733386
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFBR1
Name: transforming growth factor beta receptor 1
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFBR1increases expressionISOTgfbr1 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of TGFBR1 mRNAPMID:28181416 PMID:34492290
TGFBR1increases response to substanceISOTgfbr1 (Mus musculus)6480464CTDTGFBR1 protein results in increased susceptibility to ThioacetamidePMID:28560358
TGFBR1multiple interactionsISOTgfbr1 (Rattus norvegicus)6480464CTD[Thioacetamide co-treated with Cyclosporine] results in increased expression of TGFBR1 protein; [Thioacetamide co-treated with Lipopolysaccharides] results in increased expression of TGFBR1 mRNAPMID:15770714 PMID:17621560
TGFBR1multiple interactionsISOTgfbr1 (Mus musculus)6480464CTD[TGFBR1 protein results in increased susceptibility to Thioacetamide] which results in increased cleavage of CASP3 protein; [TGFBR1 protein results in increased susceptibility to Thioacetamide] which results in increased expression of GPT protein; TGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of CCN2 mRNA]; TGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFA mRNA]; TGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFB mRNA]; TGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]PMID:28560358
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