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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733364
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H3
Name: nuclear receptor subfamily 1 group H member 3
Acc ID: CHEBI:71260
Term: pitavastatin(1-)
Definition: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
Chemical ID: MESH:C108475
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H3multiple interactionsISONr1h3 (Mus musculus)6480464CTDNR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol]PMID:16415093
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