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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNB1
Name: cyclin B1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNB1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CCNB1 mRNA; Benzo(a)pyrene results in decreased expression of CCNB1 proteinPMID:16120219 PMID:20064835 PMID:21632981
CCNB1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CCNB1 mRNAPMID:33411230
CCNB1multiple interactionsEXP 6480464CTDBenzo(a)pyrene results in increased degradation of and results in decreased expression of CCNB1 proteinPMID:29126329
CCNB1decreases expressionISOCcnb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCNB1 mRNAPMID:17942131 PMID:22228805
CCNB1increases expressionISOCcnb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCNB1 mRNAPMID:32417428
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