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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733118
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CXCL2 mRNAPMID:21570461
Cxcl2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CXCL2 mRNAPMID:16114106 PMID:19770486 PMID:23999131 PMID:26862745 PMID:29673856
Cxcl2multiple interactionsEXP 6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CXCL2 mRNA; AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CXCL2 promoter]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]PMID:19654925 PMID:23999131 PMID:25975270 PMID:26862745
Cxcl2affects expressionISOCxcl2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CXCL2 mRNAPMID:22298810
Cxcl2affects expressionISOCXCL2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of CXCL2 mRNAPMID:22298810
Cxcl2increases expressionISOCxcl2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CXCL2 mRNAPMID:15644576 PMID:21724226 PMID:34747641
Cxcl2increases expressionISOCXCL2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CXCL2 mRNAPMID:20106945 PMID:21632981 PMID:28351761
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