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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 proteinPMID:22543052 PMID:31675489
BCL2increases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BCL2PMID:25697951
BCL2multiple interactionsEXP 6480464CTDERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 mRNA]PMID:22543052
BCL2decreases expressionISOBcl2 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 proteinPMID:25639565
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTDepoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 protein]]; troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 protein]PMID:25639565
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