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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:63949
Term: 2,3-bis(4-hydroxyphenyl)propionitrile
Definition: A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).
Chemical ID: MESH:C486182
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2increases expressionEXP 6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 mRNA; 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 proteinPMID:19264808
BCL2multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 protein]; ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 mRNA]PMID:19264808
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile promotes the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BCL2 protein]PMID:24216299
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