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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDDecitabine results in decreased expression of BCL2 mRNA; Decitabine results in decreased expression of BCL2 proteinPMID:18636160 PMID:22082530
BCL2increases expressionEXP 6480464CTDDecitabine results in increased expression of BCL2 mRNAPMID:21515334
BCL2multiple interactionsEXP 6480464CTD[Decitabine co-treated with epigallocatechin gallate] affects the expression of BCL2 mRNA; Decitabine inhibits the reaction [Estradiol affects the expression of BCL2 mRNA]; Decitabine inhibits the reaction [tetraethoxysilane analog results in increased methylation of BCL2 promoter]PMID:18250043 PMID:22082530 PMID:27362941
BCL2increases expressionISOBcl2 (Mus musculus)6480464CTDDecitabine results in increased expression of BCL2 mRNAPMID:27915011
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD[Paraquat co-treated with Decitabine] results in decreased expression of BCL2 protein; Decitabine inhibits the reaction [Benzene results in decreased expression of BCL2 mRNA]PMID:21143203 PMID:22796470
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