GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | BCL2 | decreases expression | EXP | | 6480464 | CTD | Celecoxib results in decreased expression of BCL2 protein | PMID:15911099 PMID:16391871 PMID:17612393 PMID:26586936 | BCL2 | increases expression | EXP | | 6480464 | CTD | Celecoxib results in increased expression of BCL2 mRNA | PMID:17342322 | BCL2 | multiple interactions | EXP | | 6480464 | CTD | BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [Docetaxel results in increased expression of BCL2 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased expression of BCL2 protein]; tetraarsenic tetrasulfide promotes the reaction [Celecoxib results in decreased expression of BCL2 protein] | PMID:15688368 PMID:20104024 PMID:26586936 | BCL2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein] | PMID:16230411 | |
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