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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:30145
Term: lithium atom
Definition: An alkali metal atom that has formula Li.
Chemical ID: MESH:D008094
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2multiple interactionsEXP 6480464CTD[Lithium Chloride results in increased abundance of Lithium] promotes the reaction [Paraquat results in increased expression of BCL2 mRNA]; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BCL2 mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BCL2 protein; [Paraquat co-treated with [Lithium Chloride results in increased abundance of Lithium]] results in increased expression of BCL2 protein; Lithium inhibits the reaction [Ethanol results in decreased expression of BCL2 mRNA]PMID:21878650 PMID:26074776
BCL2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDLithium results in increased expression of BCL2; Lithium results in increased expression of BCL2 mRNA; Lithium results in increased expression of BCL2 proteinPMID:10762662 PMID:15581403 PMID:16288908
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDLithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]PMID:10762662 PMID:18976035 PMID:19149911 PMID:20455018
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