GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc40a1 | affects metabolic processing | EXP | | 6480464 | CTD | SLC40A1 protein affects the metabolism of Iron | PMID:17194590 | Slc40a1 | decreases export | EXP | | 6480464 | CTD | SLC40A1 protein mutant form results in decreased export of Iron | PMID:16457665 | Slc40a1 | decreases expression | EXP | | 6480464 | CTD | Iron results in decreased expression of SLC40A1 protein | PMID:22659129 | Slc40a1 | increases export | EXP | | 6480464 | CTD | SLC40A1 protein mutant form results in increased export of Iron; SLC40A1 protein results in increased export of Iron | PMID:16457665 PMID:21303654 | Slc40a1 | increases expression | EXP | | 6480464 | CTD | Iron deficiency results in increased expression of SLC40A1 mRNA; Iron results in increased expression of SLC40A1 mRNA | PMID:16565419 PMID:16648237 PMID:18648087 PMID:23776592 | Slc40a1 | multiple interactions | EXP | | 6480464 | CTD | [HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA]; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 protein]; NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron] | PMID:17018382 PMID:19061943 PMID:19913091 PMID:21303654 PMID:33393188 | Slc40a1 | decreases expression | ISO | Slc40a1 (Rattus norvegicus) | 6480464 | CTD | Iron results in decreased expression of SLC40A1 protein | PMID:22659129 | Slc40a1 | increases expression | ISO | Slc40a1 (Rattus norvegicus) | 6480464 | CTD | Iron deficiency results in increased expression of SLC40A1 mRNA | PMID:19821111 PMID:21540277 | Slc40a1 | multiple interactions | ISO | SLC40A1 (Homo sapiens) | 6480464 | CTD | [CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]; Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese] | PMID:20655381 PMID:22178646 | | ||||||||||||||||||||||
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