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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733058
Species: Homo sapiens
RGD Object: Gene
Symbol: MC4R
Name: melanocortin 4 receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MC4R ISOMc4r (Rattus norvegicus)329951016RGDbisphenol A decreases expression of MC4R mRNA and protein in rat liver 
MC4Rmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of MC4R genePMID:31601247
MC4Rdecreases expressionISOMc4r (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of MC4R mRNAPMID:22957036 PMID:25181051 PMID:30816183 PMID:32528016
MC4Rincreases expressionISOMc4r (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of MC4R mRNAPMID:34947998
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