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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733019
Species: Homo sapiens
RGD Object: Gene
Symbol: PRDX2
Name: peroxiredoxin 2
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDFormaldehyde results in decreased expression of PRDX2 mRNA, Formaldehyde results in decreased expression of PRDX2 protein

PMID:20347000, PMID:27664576
multiple interactionsEXP 6480464CTDPRDX2 protein inhibits the reaction [Formaldehyde results in increased activity of CASP3 protein], PRDX2 protein inhibits the reaction [Formaldehyde results in increased activity of CASP9 protein], PRDX2 protein inhibits the reaction [Formaldehyde results in increased expression of BAX protein], PRDX2 protein inhibits the reaction [Formaldehyde results in increased expression of BCL2 protein], SB 203580 inhibits the reaction [Formaldehyde results in decreased expression of PRDX2 protein]

PMID:20347000
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.