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GENE - TERM ANNOTATION REPORT

RGD ID: 732989
Species: Homo sapiens
RGD Object: Gene
Symbol: PLCG2
Name: phospholipase C gamma 2
Acc ID: GO:0004435
Term: phosphatidylinositol phospholipase C activity
Definition: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+.
Definition Source(s): EC:3.1.4.11, RHEA:33179
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLCG2 ISOPlcg2 (Rattus norvegicus)9068941RGD PMID:2557343 REF_RGD_ID:69934
PLCG2enablesIMP 150520179ARUK-UCL PMID:32514138

PMID:32514138
PLCG2enablesIBAFB:FBgn0262738 or MGI:2150308 or MGI:97613 or MGI:97615 or MGI:97616 or PANTHER:PTN007434641 or Plcb1 (Rattus norvegicus) or Plcd1 (Rattus norvegicus) or Plcg1 (Rattus norvegicus) or Plcg2 (Rattus norvegicus) or Plcb3 (Rattus norvegicus) or Plcb2 (Rattus norvegicus) or Plcd4 (Rattus norvegicus) or Plce1 (Rattus norvegicus) or SGD:S000006189 or TAIR:locus:2075696 or UniProtKB:O75038 or UniProtKB:P10894 or UniProtKB:P16885 or UniProtKB:P19174 or UniProtKB:P51178 or UniProtKB:Q00722 or UniProtKB:Q01970 or UniProtKB:Q86YW0 or UniProtKB:Q9NQ66 or UniProtKB:Q9P212 or WB:WBGene00004036 or dictyBase:DDB_G0292736150520179GO_Central GO_REF:0000033
PLCG2enablesIEAInterPro:IPR001711 or InterPro:IPR016279150520179InterPro GO_REF:0000002
PLCG2enablesIEARHEA:33179150520179RHEA GO_REF:0000116
PLCG2enablesTAS 150520179Reactome Reactome:R-HSA-2730847 Reactome:R-HSA-5607735
PLCG2enablesIDA 150520179UniProt PMID:11606584 PMID:12181444

PMID:11606584 PMID:12181444
PLCG2enablesIEAARBA:ARBA00028561150520179UniProt GO_REF:0000117
PLCG2enablesIEAEC:3.1.4.11150520179UniProt GO_REF:0000003
PLCG2enablesIEAUniRule:UR000925796150520179UniProt GO_REF:0000104
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