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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732982
Species: Mus musculus
RGD Object: Gene
Symbol: Tpp1
Name: tripeptidyl peptidase I
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpp1affects expressionISOTPP1 (Homo sapiens)6480464CTDValproic Acid affects the expression of TPP1 mRNAPMID:25979313
Tpp1increases expressionISOTPP1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of TPP1 mRNAPMID:19101580 PMID:23179753 PMID:25192806 PMID:27188386 PMID:28001369
Tpp1increases methylationISOTPP1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of TPP1 genePMID:29154799
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