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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732968
Species: Homo sapiens
RGD Object: Gene
Symbol: XRCC1
Name: X-ray repair cross complementing 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XRCC1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XRCC1 mRNA]PMID:18948301
XRCC1multiple interactionsISOXrcc1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [XRCC1 gene mutant form results in decreased abundance of Adenosine Triphosphate]; Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in increased abundance of Malondialdehyde]; Acetylcysteine promotes the reaction [XRCC1 protein results in decreased abundance of Malondialdehyde]; Acetylcysteine promotes the reaction [XRCC1 protein results in decreased oxidation of Glutathione]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased abundance of Adenosine Triphosphate]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased activity of CAT protein]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of CYTB mRNA]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND2 mRNA]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND5 mRNA]PMID:30998386
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