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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732955
Species: Mus musculus
RGD Object: Gene
Symbol: Dusp1
Name: dual specificity phosphatase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp1affects response to substanceEXP 6480464CTDDUSP1 protein affects the susceptibility to ResveratrolPMID:30844440
Dusp1multiple interactionsEXP 6480464CTDDUSP1 protein affects the reaction [Resveratrol affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; DUSP1 protein affects the reaction [Resveratrol affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; DUSP1 protein affects the reaction [Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]; Resveratrol inhibits the reaction [titanium dioxide results in increased expression of DUSP1 mRNA]PMID:30844440 PMID:31298478
Dusp1decreases expressionISODusp1 (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of DUSP1 mRNAPMID:19228061
Dusp1multiple interactionsISODUSP1 (Homo sapiens)6480464CTD[Coumestrol co-treated with resveratrol] results in decreased expression of DUSP1 mRNA; DUSP1 protein inhibits the reaction [resveratrol results in increased activity of EGR1 protein]PMID:19167446 PMID:25645941
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