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GENE - TERM ANNOTATION REPORT

RGD ID: 732948
Species: Homo sapiens
RGD Object: Gene
Symbol: UFD1
Name: ubiquitin recognition factor in ER associated degradation 1
Acc ID: GO:0034098
Term: VCP-NPL4-UFD1 AAA ATPase complex
Definition: A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
Definition Source(s): PMID:11813000, PMID:16179952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UFD1located_inIPI 150520179ComplexPortal PMID:20414249

PMID:20414249
UFD1part_ofIEAUniProtKB:P70362 or ensembl:ENSMUSP00000111241150520179Ensembl GO_REF:0000107
UFD1part_ofIBAMGI:109353 or PANTHER:PTN000285104 or Ufd1 (Rattus norvegicus) or SGD:S000003280 or UniProtKB:Q92890 or WB:WBGene00006733150520179GO_Central GO_REF:0000033
UFD1part_ofISSUniProtKB:Q9ES53150520179ParkinsonsUK-UCL GO_REF:0000024
UFD1part_ofIEAPANTHER:PTHR12555:SF13150520179TreeGrafter GO_REF:0000118
UFD1part_ofIDA 150520179UniProt PMID:26471729

PMID:26471729
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