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GENE - TERM ANNOTATION REPORT

RGD ID: 732939
Species: Homo sapiens
RGD Object: Gene
Symbol: OTC
Name: ornithine transcarbamylase
Acc ID: GO:0000050
Term: urea cycle
Definition: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Definition Source(s): GOC:pde, GOC:vw, ISBN:0198506732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OTC ISOOtc (Rattus norvegicus)9068941RGD PMID:3680220 PMID:4062872 REF_RGD_ID:1582379 REF_RGD_ID:2300098
OTCinvolved_inIDA 150520179BHF-UCL PMID:2556444

PMID:2556444
OTCinvolved_inIEAUniProtKB:P00481 or ensembl:ENSRNOP00000004686150520179Ensembl GO_REF:0000107
OTCinvolved_inIEAUniPathway:UPA00158150520179UniProt GO_REF:0000041
OTCinvolved_inIEAUniProtKB-KW:KW-0835150520179UniProt GO_REF:0000043
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