GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SLC6A4 | decreases activity | EXP | | 6480464 | CTD | Cocaine results in decreased activity of SLC6A4 protein | PMID:18321529 | SLC6A4 | increases expression | EXP | | 6480464 | CTD | Cocaine results in increased expression of SLC6A4 protein | PMID:11207425 | SLC6A4 | multiple interactions | EXP | | 6480464 | CTD | Cocaine binds to and results in decreased activity of SLC6A4 protein; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]; Cocaine inhibits the reaction [SLC6A4 protein results in increased uptake of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium] | PMID:16272152 PMID:28506818 PMID:33785354 | SLC6A4 | affects expression | ISO | Slc6a4 (Rattus norvegicus) | 6480464 | CTD | Cocaine affects the expression of SLC6A4 mRNA | PMID:11072100 | SLC6A4 | affects response to substance | ISO | Slc6a4 (Mus musculus) | 6480464 | CTD | SLC6A4 mutant form affects the susceptibility to Cocaine | PMID:11320258 | SLC6A4 | decreases response to substance | ISO | Slc6a4 (Rattus norvegicus) | 6480464 | CTD | SLC6A4 results in decreased susceptibility to Cocaine | PMID:18581099 | SLC6A4 | increases response to substance | ISO | Slc6a4 (Rattus norvegicus) | 6480464 | CTD | SLC6A4 gene mutant form results in increased susceptibility to Cocaine | PMID:20459657 | | ||||||||||||||||||||||
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