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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionEXP 6480464CTDarsenite results in decreased expression of CDKN1A mRNA; arsenite results in decreased expression of CDKN1A proteinPMID:16739126 PMID:18191166 PMID:18929588
Cdkn1aincreases expressionEXP 6480464CTDarsenite results in increased expression of CDKN1A mRNA; arsenite results in increased expression of CDKN1A proteinPMID:23396362 PMID:33010264
Cdkn1amultiple interactionsEXP 6480464CTDAKT1 protein modified form inhibits the reaction [arsenite results in increased expression of CDKN1A protein]; NFKB1 protein affects the reaction [arsenite results in increased expression of CDKN1A protein]; Sirolimus inhibits the reaction [arsenite results in increased expression of CDKN1A protein]; TRP53 protein affects the reaction [arsenite results in decreased expression of CDKN1A mRNA]PMID:18929588 PMID:23396362
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDarsenite results in decreased expression of CDKN1A mRNAPMID:22447124
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDarsenite results in increased expression of CDKN1A proteinPMID:23715767
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDarsenite promotes the reaction [G3BP1 protein binds to CDKN1A mRNA]; EPAS1 protein affects the reaction [arsenite results in decreased expression of CDKN1A mRNA]PMID:22447124 PMID:32406909
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