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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionEXP 6480464CTDSodium Fluoride affects the expression of CDKN1A proteinPMID:30738887
Cdkn1amultiple interactionsEXP 6480464CTDSRT1720 affects the reaction [Sodium Fluoride affects the expression of CDKN1A protein]PMID:30738887
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDSodium Fluoride results in decreased expression of CDKN1A mRNA; Sodium Fluoride results in decreased expression of CDKN1A proteinPMID:31669217
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDSodium Fluoride results in increased expression of CDKN1A mRNA; Sodium Fluoride results in increased expression of CDKN1A proteinPMID:22525295
Cdkn1aincreases methylationISOCDKN1A (Homo sapiens)6480464CTDSodium Fluoride results in increased methylation of CDKN1A promoterPMID:31669217
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDDecitabine inhibits the reaction [Sodium Fluoride results in decreased expression of CDKN1A mRNA]; Decitabine inhibits the reaction [Sodium Fluoride results in decreased expression of CDKN1A protein]; Decitabine inhibits the reaction [Sodium Fluoride results in increased methylation of CDKN1A promoter]PMID:31669217
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