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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases expressionEXP 6480464CTDRotenone results in decreased expression of AKT1 mRNAPMID:33512557
AKT1decreases phosphorylationEXP 6480464CTDRotenone results in decreased phosphorylation of AKT1 proteinPMID:28245986 PMID:34182063
AKT1multiple interactionsEXP 6480464CTD1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; PHLPP1 protein affects the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; PHLPP1 protein inhibits the reaction [FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]PMID:28245986 PMID:34182063
AKT1affects phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDRotenone affects the phosphorylation of AKT1 proteinPMID:19781600
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDRotenone results in decreased phosphorylation of AKT1 proteinPMID:25433145 PMID:28245986 PMID:29174113 PMID:34182063 PMID:35833337
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDRotenone results in decreased phosphorylation of AKT1 proteinPMID:36048341 PMID:36774383
AKT1increases expressionISOAkt1 (Mus musculus)6480464CTDRotenone results in increased expression of AKT1 mRNAPMID:26806867
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; GHRL protein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; GHSR protein affects the reaction [GHRL protein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; nootkatone inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]PMID:25433145 PMID:28245986 PMID:29174113 PMID:34182063 PMID:35833337
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTDChlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; oleuropein inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]; Rotenone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]PMID:30857887 PMID:36048341 PMID:36774383
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