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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732873
Species: Homo sapiens
RGD Object: Gene
Symbol: NR0B2
Name: nuclear receptor subfamily 0 group B member 2
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR0B2increases expressionEXP 6480464CTDLithocholic Acid results in increased expression of NR0B2 mRNA; Lithocholic Acid results in increased expression of NR0B2 proteinPMID:19562681 PMID:22540009 PMID:25055961 PMID:30419252
NR0B2multiple interactionsEXP 6480464CTD[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNAPMID:17963371
NR0B2decreases expressionISONr0b2 (Mus musculus)6480464CTDLithocholic Acid results in decreased expression of NR0B2 mRNAPMID:20359477
NR0B2increases expressionISONr0b2 (Rattus norvegicus)6480464CTDLithocholic Acid results in increased expression of NR0B2 mRNAPMID:20888898
NR0B2increases expressionISONr0b2 (Mus musculus)6480464CTDLithocholic Acid results in increased expression of NR0B2 mRNAPMID:22982774 PMID:25582706
NR0B2multiple interactionsISONr0b2 (Rattus norvegicus)6480464CTD[Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNAPMID:19562681
NR0B2multiple interactionsISONr0b2 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNAPMID:20359477
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