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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732865
Species: Homo sapiens
RGD Object: Gene
Symbol: PRKAA1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:31205
Term: amlexanox
Definition: A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Chemical ID: MESH:C045742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRKAA1increases phosphorylationISOPrkaa1 (Mus musculus)6480464CTDamlexanox results in increased phosphorylation of PRKAA1 proteinPMID:31697998
PRKAA1multiple interactionsISOPrkaa1 (Mus musculus)6480464CTD[Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]PMID:31697998
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