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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732857
Species: Mus musculus
RGD Object: Gene
Symbol: Il12b
Name: interleukin 12b
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12bincreases expressionEXP 6480464CTDDinoprostone results in increased expression of IL12B proteinPMID:15180965
Il12bmultiple interactionsEXP 6480464CTDCSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]; Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]PMID:15180965
Il12bincreases expressionISOIL12B (Homo sapiens)6480464CTDDinoprostone results in increased expression of IL12B mRNA; Dinoprostone results in increased expression of IL12B proteinPMID:11369638 PMID:16303787
Il12bincreases secretionISOIL12B (Homo sapiens)6480464CTDDinoprostone results in increased secretion of IL12B proteinPMID:11369638
Il12bmultiple interactionsISOIL12B (Homo sapiens)6480464CTD[TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]PMID:10614771 PMID:11369638
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