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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732850
Species: Homo sapiens
RGD Object: Gene
Symbol: PNMT
Name: phenylethanolamine N-methyltransferase
Acc ID: CHEBI:28487
Term: reserpine
Definition: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chemical ID: MESH:D012110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PNMTdecreases expressionISOPnmt (Rattus norvegicus)6480464CTDReserpine results in decreased expression of PNMT mRNAPMID:1687976 PMID:1714554 PMID:20504635 PMID:2903502
PNMTincreases expressionISOPnmt (Rattus norvegicus)6480464CTDReserpine results in increased expression of PNMT mRNAPMID:1359376 PMID:2903502 PMID:8063705 PMID:8479280
PNMTmultiple interactionsISOPnmt (Rattus norvegicus)6480464CTDChlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT proteinPMID:1714554 PMID:20504635 PMID:8479280
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