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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732779
Species: Mus musculus
RGD Object: Gene
Symbol: Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r12aincreases phosphorylationISOPPP1R12A (Homo sapiens)6480464CTDColforsin results in increased phosphorylation of PPP1R12A proteinPMID:21474433
Ppp1r12amultiple interactionsISOPPP1R12A (Homo sapiens)6480464CTDCapsaicin inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]; capsazepine inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]PMID:21474433
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