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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732764
Species: Homo sapiens
RGD Object: Gene
Symbol: CHRNB4
Name: cholinergic receptor nicotinic beta 4 subunit
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNB4multiple interactionsEXP 6480464CTDNicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]PMID:34628512 PMID:9454827
CHRNB4affects response to substanceISOChrnb4 (Mus musculus)6480464CTDCHRNB4 protein affects the susceptibility to NicotinePMID:15275829
CHRNB4increases activityISOChrnb4 (Rattus norvegicus)6480464CTDNicotine results in increased activity of CHRNB4 proteinPMID:19483072
CHRNB4increases expressionISOChrnb4 (Mus musculus)6480464CTDNicotine results in increased expression of CHRNB4 mRNAPMID:29293602
CHRNB4multiple interactionsISOChrnb4 (Rattus norvegicus)6480464CTDNicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:11600638 PMID:15615518
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