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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732757
Species: Homo sapiens
RGD Object: Gene
Symbol: PTK2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:75253
Term: phenylarsine oxide
Definition: An arsine oxide derived from phenylarsine.
Chemical ID: MESH:C029341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTK2increases phosphorylationEXP 6480464CTDoxophenylarsine results in increased phosphorylation of PTK2 proteinPMID:10537051
PTK2multiple interactionsEXP 6480464CTD[oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]PMID:10537051 PMID:10569804
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