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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732752
Species: Mus musculus
RGD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a1increases expressionEXP 6480464CTDColforsin results in increased expression of NR4A1 mRNA; Colforsin results in increased expression of NR4A1 proteinPMID:23183170 PMID:8164692
Nr4a1multiple interactionsEXP 6480464CTD[Colforsin co-treated with deoxynivalenol] results in increased expression of NR4A1 mRNA; Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]PMID:23183170 PMID:26783879
Nr4a1multiple interactionsISONR4A1 (Homo sapiens)6480464CTDNR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]PMID:19822197
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