GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ARNT | affects localization | EXP | | 6480464 | CTD | Benzo(a)pyrene affects the localization of ARNT protein | PMID:26350169 | ARNT | affects methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene affects the methylation of ARNT intron | PMID:30157460 | ARNT | affects response to substance | EXP | | 6480464 | CTD | ARNT protein affects the susceptibility to Benzo(a)pyrene | PMID:28882572 | ARNT | decreases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ARNT mRNA | PMID:21256954 | ARNT | decreases methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of ARNT 3' UTR | PMID:27901495 | ARNT | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ARNT mRNA | PMID:18247414 | ARNT | increases methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ARNT promoter | PMID:27901495 | ARNT | multiple interactions | EXP | | 6480464 | CTD | [AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Benzo(a)pyrene; ARNT protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; ARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]; Benzo(a)pyrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]; Quercetin promotes the reaction [Benzo(a)pyrene results in decreased expression of ARNT mRNA] | PMID:11768231 PMID:16972788 PMID:20228066 PMID:21256954 PMID:21507987 PMID:24486526 PMID:26303333 PMID:28882572 | ARNT | decreases expression | ISO | Arnt (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ARNT mRNA | PMID:22228805 | ARNT | increases expression | ISO | Arnt (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ARNT mRNA | PMID:26303333 PMID:26466350 | ARNT | increases response to substance | ISO | Arnt (Mus musculus) | 6480464 | CTD | ARNT protein results in increased susceptibility to Benzo(a)pyrene | PMID:19755658 | ARNT | multiple interactions | ISO | Arnt (Mus musculus) | 6480464 | CTD | [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of ARNT mRNA | PMID:28987381 | ARNT | multiple interactions | ISO | Arnt (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene inhibits the reaction [ARNT protein binds to GNMT protein]; Benzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]; INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]; Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]; wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]] | PMID:21445860 PMID:26303333 PMID:26466350 | |
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