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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732739
Species: Homo sapiens
RGD Object: Gene
Symbol: ARNT
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARNTaffects localizationEXP 6480464CTDBenzo(a)pyrene affects the localization of ARNT proteinPMID:26350169
ARNTaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of ARNT intronPMID:30157460
ARNTaffects response to substanceEXP 6480464CTDARNT protein affects the susceptibility to Benzo(a)pyrenePMID:28882572
ARNTdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of ARNT mRNAPMID:21256954
ARNTdecreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of ARNT 3' UTRPMID:27901495
ARNTincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ARNT mRNAPMID:18247414
ARNTincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of ARNT promoterPMID:27901495
ARNTmultiple interactionsEXP 6480464CTD[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Benzo(a)pyrene; ARNT protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; ARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]; Benzo(a)pyrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]; Quercetin promotes the reaction [Benzo(a)pyrene results in decreased expression of ARNT mRNA]PMID:11768231 PMID:16972788 PMID:20228066 PMID:21256954 PMID:21507987 PMID:24486526 PMID:26303333 PMID:28882572
ARNTdecreases expressionISOArnt (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ARNT mRNAPMID:22228805
ARNTincreases expressionISOArnt (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of ARNT mRNAPMID:26303333 PMID:26466350
ARNTincreases response to substanceISOArnt (Mus musculus)6480464CTDARNT protein results in increased susceptibility to Benzo(a)pyrenePMID:19755658
ARNTmultiple interactionsISOArnt (Mus musculus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of ARNT mRNAPMID:28987381
ARNTmultiple interactionsISOArnt (Rattus norvegicus)6480464CTDBenzo(a)pyrene inhibits the reaction [ARNT protein binds to GNMT protein]; Benzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]; INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]; Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]; wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]PMID:21445860 PMID:26303333 PMID:26466350
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