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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732685
Species: Mus musculus
RGD Object: Gene
Symbol: Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1increases expressionEXP 6480464CTDFenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 proteinPMID:17118139 PMID:17690133 PMID:23063693 PMID:24752549 PMID:24986865
Acox1multiple interactionsEXP 6480464CTDFenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein]PMID:23063693 PMID:24752549 PMID:24986865 PMID:28871336
Acox1affects expressionISOAcox1 (Rattus norvegicus)6480464CTDFenofibrate affects the expression of ACOX1 mRNAPMID:20801182
Acox1increases expressionISOACOX1 (Homo sapiens)6480464CTDFenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 proteinPMID:24752549 PMID:24986865 PMID:25572481 PMID:30611848
Acox1increases expressionISOAcox1 (Rattus norvegicus)6480464CTDFenofibrate results in increased expression of ACOX1 mRNAPMID:16707586 PMID:18775883 PMID:19395589 PMID:22301950 PMID:32741897
Acox1multiple interactionsISOACOX1 (Homo sapiens)6480464CTD[Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of ACOX1 protein; [Fenofibrate co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein]PMID:24534255 PMID:24735863 PMID:24752549
Acox1multiple interactionsISOAcox1 (Rattus norvegicus)6480464CTD[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNAPMID:18253720 PMID:18775883
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