GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Acox1 | increases expression | EXP | | 6480464 | CTD | Fenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 protein | PMID:17118139 PMID:17690133 PMID:23063693 PMID:24752549 PMID:24986865 | Acox1 | multiple interactions | EXP | | 6480464 | CTD | Fenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein] | PMID:23063693 PMID:24752549 PMID:24986865 PMID:28871336 | Acox1 | affects expression | ISO | Acox1 (Rattus norvegicus) | 6480464 | CTD | Fenofibrate affects the expression of ACOX1 mRNA | PMID:20801182 | Acox1 | increases expression | ISO | ACOX1 (Homo sapiens) | 6480464 | CTD | Fenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 protein | PMID:24752549 PMID:24986865 PMID:25572481 PMID:30611848 | Acox1 | increases expression | ISO | Acox1 (Rattus norvegicus) | 6480464 | CTD | Fenofibrate results in increased expression of ACOX1 mRNA | PMID:16707586 PMID:18775883 PMID:19395589 PMID:22301950 PMID:32741897 | Acox1 | multiple interactions | ISO | ACOX1 (Homo sapiens) | 6480464 | CTD | [Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of ACOX1 protein; [Fenofibrate co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein] | PMID:24534255 PMID:24735863 PMID:24752549 | Acox1 | multiple interactions | ISO | Acox1 (Rattus norvegicus) | 6480464 | CTD | [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNA | PMID:18253720 PMID:18775883 | |
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