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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732685
Species: Mus musculus
RGD Object: Gene
Symbol: Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1increases expressionEXP 6480464CTDBezafibrate results in increased expression of ACOX1 mRNA; Bezafibrate results in increased expression of ACOX1 proteinPMID:12782154 PMID:15447978 PMID:16574099 PMID:17118139 PMID:21324916 PMID:21640707
Acox1multiple interactionsEXP 6480464CTD[Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ACOX1 mRNA; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]PMID:11929713 PMID:12782154 PMID:21324916 PMID:21549692
Acox1increases activityISOAcox1 (Rattus norvegicus)6480464CTDBezafibrate results in increased activity of ACOX1 proteinPMID:11172741 PMID:2399535
Acox1increases expressionISOACOX1 (Homo sapiens)6480464CTDBezafibrate results in increased expression of ACOX1 mRNAPMID:21640707
Acox1increases expressionISOAcox1 (Rattus norvegicus)6480464CTDBezafibrate results in increased expression of ACOX1 mRNAPMID:11172741 PMID:11216866 PMID:11473052 PMID:11519881 PMID:11527545 PMID:11579993 PMID:16707586
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