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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732638
Species: Mus musculus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparadecreases response to substanceEXP 6480464CTDPPARA gene mutant form results in decreased susceptibility to PermethrinPMID:30629241
Pparaincreases activityEXP 6480464CTDPermethrin results in increased activity of PPARA proteinPMID:30629241
Pparamultiple interactionsEXP 6480464CTD[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA]PMID:29751049
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDPermethrin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]PMID:30738135
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