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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732638
Species: Mus musculus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparaincreases expressionEXP 6480464CTDQuercetin results in increased expression of PPARA mRNAPMID:25204422
Pparamultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA mRNA]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]; Quercetin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of PPARA mRNA]PMID:21462320 PMID:22447684 PMID:25204422 PMID:25712622
Pparamultiple interactionsISOPpara (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Quercetin inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]PMID:22426011 PMID:23647015
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]; Quercetin inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Quercetin inhibits the reaction [GW 7647 results in increased activity of PPARA protein]PMID:18393431 PMID:23647015 PMID:25712622
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