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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732606
Species: Mus musculus
RGD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone, beta subunit
Acc ID: CHEBI:17606
Term: diiodine
Definition: Molecule comprising two covalently bonded iodine atoms with overall zero charge..
Chemical ID: MESH:D007455
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tshbaffects abundanceISOTSHB (Homo sapiens)6480464CTDTSHB protein affects the abundance of IodinePMID:16030158
Tshbincreases secretionISOTshb (Rattus norvegicus)6480464CTDIodine deficiency results in increased secretion of TSHB proteinPMID:20882593
Tshbmultiple interactionsISOTshb (Rattus norvegicus)6480464CTD[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB proteinPMID:30090431
Tshbmultiple interactionsISOTSHB (Homo sapiens)6480464CTDefavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]PMID:16030158
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