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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732584
Species: Mus musculus
RGD Object: Gene
Symbol: Col3a1
Name: collagen, type III, alpha 1
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col3a1multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]PMID:29355602 PMID:31706003
Col3a1decreases expressionISOCol3a1 (Rattus norvegicus)6480464CTDandrographolide results in decreased expression of COL3A1 mRNAPMID:29355602
Col3a1decreases expressionISOCOL3A1 (Homo sapiens)6480464CTDandrographolide results in decreased expression of COL3A1 mRNAPMID:29355602
Col3a1multiple interactionsISOCOL3A1 (Homo sapiens)6480464CTDandrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]PMID:29355602
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