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GENE - TERM ANNOTATION REPORT

RGD ID: 732576
Species: Homo sapiens
RGD Object: Gene
Symbol: CACNB2
Name: calcium voltage-gated channel auxiliary subunit beta 2
Acc ID: DOID:9000184
Term: Ventricular Fibrillation
Definition: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Definition Source(s): MESH:D014693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CACNB2 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Ventricular fibrillationPMID:28492532
CACNB2 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Early repolarization associated with ventricular fibrillationPMID:20817017 PMID:22840528 PMID:23861362 PMID:24033266 PMID:24055113 PMID:25741868 PMID:26707467 PMID:27650965 PMID:28492532 PMID:30027834
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