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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732555
Species: Homo sapiens
RGD Object: Gene
Symbol: GJB1
Name: gap junction protein beta 1
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJB1decreases expressionISOGjb1 (Rattus norvegicus)6480464CTDHexachlorobenzene results in decreased expression of GJB1 mRNA; Hexachlorobenzene results in decreased expression of GJB1 proteinPMID:12117784 PMID:17150971
GJB1multiple interactionsISOGjb1 (Rattus norvegicus)6480464CTDAKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Estradiol affects the reaction [Hexachlorobenzene results in increased expression of GJB1 mRNA]PMID:12117784 PMID:17150971
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