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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732539
Species: Mus musculus
RGD Object: Gene
Symbol: Bid
Name: BH3 interacting domain death agonist
Acc ID: CHEBI:47344
Term: alvocidib
Definition: A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
Chemical ID: MESH:C077990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bidincreases cleavageISOBID (Homo sapiens)6480464CTDalvocidib results in increased cleavage of BID proteinPMID:11464216 PMID:12170773
Bidmultiple interactionsISOBID (Homo sapiens)6480464CTD[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of BID protein; [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of BID protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of BID protein]PMID:11464216 PMID:12170773 PMID:12231544 PMID:15634644 PMID:16951203
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