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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732528
Species: Mus musculus
RGD Object: Gene
Symbol: Nat2
Name: N-acetyltransferase 2 (arylamine N-acetyltransferase)
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat2affects activityISONAT2 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of NAT2 polymorphismPMID:37423373
Nat2decreases expressionISONAT2 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT2 mRNAPMID:22138251
Nat2increases activityISONAT2 (Homo sapiens)6480464CTDNAT2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; NAT2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:15110095
Nat2increases expressionISONAT2 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAT2 mRNAPMID:29549414
Nat2multiple interactionsISONAT2 (Homo sapiens)6480464CTD[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of NAT2 polymorphism] which affects the chemical synthesis of GlucosePMID:37423373
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