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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732524
Species: Homo sapiens
RGD Object: Gene
Symbol: CYSLTR1
Name: cysteinyl leukotriene receptor 1
Acc ID: CHEBI:50730
Term: montelukast
Definition: An aliphatic sulfide that has formula 586.18398.
Chemical ID: MESH:C093875
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYSLTR1multiple interactionsEXP 6480464CTDalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]; montelukast binds to and results in decreased activity of CYSLTR1 protein; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]PMID:10391245 PMID:10462554 PMID:10851239 PMID:11006272 PMID:11996896 PMID:12853847 PMID:14718577 PMID:18651869 PMID:20083671 PMID:9620942
CYSLTR1decreases expressionISOCysltr1 (Mus musculus)6480464CTDmontelukast results in decreased expression of CYSLTR1 mRNAPMID:19544365
CYSLTR1multiple interactionsISOCysltr1 (Rattus norvegicus)6480464CTDmontelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA]PMID:30222980
CYSLTR1multiple interactionsISOCysltr1 (Mus musculus)6480464CTDmontelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]; montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]PMID:27702591
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