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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732520
Species: Homo sapiens
RGD Object: Gene
Symbol: BMAL1
Name: basic helix-loop-helix ARNT like 1
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMAL1increases expressionEXP 6480464CTDbeta-Naphthoflavone results in increased expression of BMAL1 mRNAPMID:32151702
BMAL1multiple interactionsISOBmal1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of BMAL1 mRNAPMID:18164116
BMAL1multiple interactionsISOBmal1 (Mus musculus)6480464CTDbeta-Naphthoflavone inhibits the reaction [CLOCK protein binds to BMAL1 protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to BMAL1 protein]; BMAL1 affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]PMID:20106950 PMID:21849270
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