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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDChloroquine results in increased phosphorylation of MAPK1 proteinPMID:31310755
Mapk1multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]PMID:22341560 PMID:28134560
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDChloroquine results in decreased phosphorylation of MAPK1 proteinPMID:32060308
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDChloroquine results in increased phosphorylation of MAPK1 proteinPMID:18055026
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK1 protein; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK1 protein]PMID:32060308
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