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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:144353
Term: diethyldithiocarbamic acid
Definition: A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.
Chemical ID: MESH:D004050
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDDitiocarb results in increased phosphorylation of MAPK1 proteinPMID:16603213
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]PMID:16603213
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