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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:73224
Term: allyl isothiocyanate
Definition: An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Chemical ID: MESH:C004471
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1decreases phosphorylationEXP 6480464CTDallyl isothiocyanate results in decreased phosphorylation of MAPK1 proteinPMID:37318315
MAPK1increases phosphorylationEXP 6480464CTDallyl isothiocyanate results in increased phosphorylation of MAPK1 proteinPMID:23219522
MAPK1multiple interactionsEXP 6480464CTD[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]PMID:23219522 PMID:23994502
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