GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPK1 | increases phosphorylation | EXP | | 6480464 | CTD | Equol results in increased phosphorylation of MAPK1 protein | PMID:16840783 PMID:21300668 | MAPK1 | multiple interactions | EXP | | 6480464 | CTD | [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Equol; AG 1879 inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein; Pertussis Toxin inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein] | PMID:16840783 PMID:19427779 PMID:21300668 | | ||||||||||||||||||||||
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