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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1multiple interactionsEXP 6480464CTD[Dichlorodiphenyl Dichloroethylene results in increased activity of AR protein mutant form] which results in increased phosphorylation of MAPK1 proteinPMID:18819937
MAPK1increases activityISOMapk1 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of MAPK1 proteinPMID:12523960
MAPK1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased phosphorylation of MAPK1 proteinPMID:12523960 PMID:15531431 PMID:17174995
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