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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1decreases phosphorylationEXP 6480464CTDLuteolin results in decreased phosphorylation of MAPK1 proteinPMID:19344998
MAPK1increases phosphorylationEXP 6480464CTDLuteolin results in increased phosphorylation of MAPK1 proteinPMID:27474067 PMID:32268164
MAPK1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; mirdametinib inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]PMID:10718847 PMID:15322261 PMID:19557821 PMID:25448439 PMID:27474067 PMID:32268164 PMID:33675858
MAPK1increases activityISOMapk1 (Rattus norvegicus)6480464CTDLuteolin results in increased activity of MAPK1 proteinPMID:17982879 PMID:22864849
MAPK1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDLuteolin results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:17950587
MAPK1multiple interactionsISOMapk1 (Mus musculus)6480464CTDLuteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]PMID:37390879
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