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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732498
Species: Homo sapiens
RGD Object: Gene
Symbol: FTH1
Name: ferritin heavy chain 1
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FTH1decreases expressionEXP 6480464CTDCarmustine results in decreased expression of FTH1 mRNAPMID:15980968
FTH1decreases response to substanceEXP 6480464CTDFTH1 results in decreased susceptibility to CarmustinePMID:21385903
FTH1multiple interactionsEXP 6480464CTDCarmustine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]PMID:16631525
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